Wales finish the group unbeaten despite failing to produce their best levels in any of their three away fixtures.
Their two previous home games had brought comprehensive wins over Montenegro and Albania, but a meeting with the Czech Republic – who are only a place below Wales in the world rankings – meant a far sterner examination.
To their credit, Wales passed the test with flying colours, despite the shock of falling behind in desperate fashion when Czech goalkeeper Olivie Lukasova's long ball forward sailed over centre-back Mayzee Davies' head and opened the home side up.
After Evans and Rhiannon Roberts failed in their attempts to plug the gap at the heart of the home rearguard, Khyrova accepted the invitation to sweep the ball beyond a helpless Safia Middleton-Patel.
This was the biggest fixture Wales have faced since the international retirement of star player Jess Fishlock last October, with Wilkinson needing others to step up with the stakes high.
They did just that, with the likes of Holland and Evans producing stand-out performances as Wales produced their most impressive performance of this campaign.
Sophie Ingle squared for the unmarked Woodham to mark her 50th cap with a sharp finish from 15 yards.
The hosts had the the better of it from that point, though the Czechs almost regained the lead just before the break when Katerina Kotrcova's shot struck the post.
Wales claimed the lead they deserved when centre-back Evans headed in after Lukasova came off her line in a failed attempt to claim Holland's floated free-kick.
Holland's blend of energy and quality produced Wales' third goal, with Griffiths on hand to wipe out any prospect of a Czech revival.
Substitute Sabina Strizova rattled Middleton-Patel's crossbar in added time, but by then Wales' job was done.
